Studies of percutaneous absorption have been performed mainly using normal skin membranes. Considering that most topical agents are supposed to be applied on 'diseased' skin lesions, it seemed quite prudent and productive to probe into such
altered
skin
conditions in the field of permeation study.
This study was designed to investigate in vitro percutaneous water absorption through physically or chemically altered guinea pig skin sections. Altered skin conditions included: taps stripping, abrasion, freezing, heating, soaking in organic
solvent,
UV irradiation and induction of contact dermatitis.
@ES The results obtained were summarized as follows;
@EN 1. Any physical or chemical insults to skin resulted, to some extent, increased percutaneous absorption.
2. Ultraviolet A(80J/cm2)and B(100J/cm2) caused different effect on percutaneous absorption.
3. Each kind of organic solvent showed different degree of effect on permeation pattern.
4. Irritant contact dermatitis resulted larger increase in absorption than allergic contact dermatitis.
5. Relative permeation ratios (total cumulative % permeation to that of normal skin) were low in tape stripping (1.25), UVA (0.86), and higher in abrasion (8.37), methanol (8.09), acetone (8.18) and irritant contact dermatitis (8.75).
|